Interleukin-27 subunit alpha (IL27)
Homo sapiens — UniProt Q8NEV9
Data last refreshed: (UniProt release unknown)
Key facts
Interleukin-27 subunit alpha (IL27) is a protein from Homo sapiens identified by UniProt accession Q8NEV9, 243 residues long. MolForge cross-references it against 0 known binders and 199 disease associations.
- UniProt accession: Q8NEV9; gene symbol IL27.
- Organism: Homo sapiens.
- Length: 243 amino acids.
- Top disease associations (Open Targets): Red cell distribution width, mean corpuscular volume and bilirubin measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Interleukin-27 subunit alpha |
|---|---|
| UniProt accession | Q8NEV9 |
| Gene | IL27 |
| Organism | Homo sapiens |
| Length | 243 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (199)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.38
- mean corpuscular volume · score 0.36
- bilirubin measurement · score 0.33
- platelet crit · score 0.31
- HbA1c measurement · score 0.30
- mean corpuscular hemoglobin concentration · score 0.27
- psoriasis · score 0.26
- Crohn's disease · score 0.26
- ulcerative colitis · score 0.25
- ankylosing spondylitis · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NEV9-F1 | alphafold | PREDICTED | 75.64 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NEV9.
Amino-acid sequence (243 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IL27?
The strongest Open Targets associations for IL27 are Red cell distribution width, mean corpuscular volume, bilirubin measurement, platelet crit and HbA1c measurement.
How long is the IL27 protein?
The Homo sapiens IL27 protein (UniProt Q8NEV9) is 243 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NEV9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NEV9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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