Interleukin-17 receptor E (IL17RE)
Homo sapiens — UniProt Q8NFR9
Data last refreshed: (UniProt release unknown)
Key facts
Interleukin-17 receptor E (IL17RE) is a protein from Homo sapiens identified by UniProt accession Q8NFR9, 667 residues long. MolForge cross-references it against 0 known binders and 90 disease associations.
- UniProt accession: Q8NFR9; gene symbol IL17RE.
- Organism: Homo sapiens.
- Length: 667 amino acids.
- Top disease associations (Open Targets): Immunodeficiency due to a late component of complements deficiency, recurrent Neisseria infections due to factor D deficiency and immunodeficiency 28.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Interleukin-17 receptor E |
|---|---|
| UniProt accession | Q8NFR9 |
| Gene | IL17RE |
| Organism | Homo sapiens |
| Length | 667 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (90)
Diseases linked to this target (Open Targets).
- Immunodeficiency due to a late component of complements deficiency · score 0.10
- recurrent Neisseria infections due to factor D deficiency · score 0.07
- immunodeficiency 28 · score 0.07
- varicella, severe recurrent · score 0.07
- candidiasis, familial, 4 · score 0.06
- Autosomal recessive early-onset inflammatory bowel disease · score 0.06
- immunodeficiency 31B · score 0.06
- type II complement component 8 deficiency · score 0.06
- Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency · score 0.06
- immunodeficiency 35 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NFR9-F1 | alphafold | PREDICTED | 68.65 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NFR9.
Amino-acid sequence (667 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IL17RE?
The strongest Open Targets associations for IL17RE are Immunodeficiency due to a late component of complements deficiency, recurrent Neisseria infections due to factor D deficiency, immunodeficiency 28, varicella, severe recurrent and candidiasis, familial, 4.
How long is the IL17RE protein?
The Homo sapiens IL17RE protein (UniProt Q8NFR9) is 667 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NFR9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NFR9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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