Olfactory receptor 4M2 (OR4M2)
Homo sapiens — UniProt Q8NGB6
Data last refreshed: (UniProt release unknown)
Key facts
Olfactory receptor 4M2 (OR4M2) is a protein from Homo sapiens identified by UniProt accession Q8NGB6, 313 residues long. MolForge cross-references it against 0 known binders and 35 disease associations.
- UniProt accession: Q8NGB6; gene symbol OR4M2.
- Organism: Homo sapiens.
- Length: 313 amino acids.
- Top disease associations (Open Targets): obesity due to melanocortin 4 receptor deficiency, CIDEC-related familial partial lipodystrophy and obesity due to prohormone convertase I deficiency.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Olfactory receptor 4M2 |
|---|---|
| UniProt accession | Q8NGB6 |
| Gene | OR4M2 |
| Organism | Homo sapiens |
| Length | 313 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (35)
Diseases linked to this target (Open Targets).
- obesity due to melanocortin 4 receptor deficiency · score 0.05
- CIDEC-related familial partial lipodystrophy · score 0.05
- obesity due to prohormone convertase I deficiency · score 0.05
- PPARG-related familial partial lipodystrophy · score 0.04
- AKT2-related familial partial lipodystrophy · score 0.04
- PLIN1-related familial partial lipodystrophy · score 0.04
- Generalized congenital lipodystrophy with myopathy · score 0.04
- LIPE-related familial partial lipodystrophy · score 0.04
- morbid obesity · score 0.04
- obesity due to congenital leptin deficiency · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NGB6-F1 | alphafold | PREDICTED | 86.09 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NGB6.
Amino-acid sequence (313 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with OR4M2?
The strongest Open Targets associations for OR4M2 are obesity due to melanocortin 4 receptor deficiency, CIDEC-related familial partial lipodystrophy, obesity due to prohormone convertase I deficiency, PPARG-related familial partial lipodystrophy and AKT2-related familial partial lipodystrophy.
How long is the OR4M2 protein?
The Homo sapiens OR4M2 protein (UniProt Q8NGB6) is 313 amino acids long.
Browse: Targets: O · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NGB6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NGB6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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