Atlastin-2 (ATL2)
Homo sapiens — UniProt Q8NHH9
Data last refreshed: (UniProt release unknown)
Key facts
Atlastin-2 (ATL2) is a protein from Homo sapiens identified by UniProt accession Q8NHH9, 583 residues long. MolForge cross-references it against 0 known binders and 86 disease associations.
- UniProt accession: Q8NHH9; gene symbol ATL2.
- Organism: Homo sapiens.
- Length: 583 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, protein measurement and multiple sclerosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Atlastin-2 |
|---|---|
| UniProt accession | Q8NHH9 |
| Gene | ATL2 |
| Organism | Homo sapiens |
| Length | 583 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (86)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- protein measurement · score 0.31
- multiple sclerosis · score 0.26
- Alzheimer disease · score 0.26
- Parkinson disease · score 0.26
- lysosomal storage disease · score 0.26
- hip bone size · score 0.24
- hip bone mineral density · score 0.24
- metabolite measurement · score 0.17
- Rheumatoid arthritis · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NHH9-F1 | alphafold | PREDICTED | 84.11 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NHH9.
Amino-acid sequence (583 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ATL2?
The strongest Open Targets associations for ATL2 are neurodegenerative disease, protein measurement, multiple sclerosis, Alzheimer disease and Parkinson disease.
How long is the ATL2 protein?
The Homo sapiens ATL2 protein (UniProt Q8NHH9) is 583 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NHH9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NHH9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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