piRNA biogenesis protein EXD1 (EXD1)

About piRNA biogenesis protein EXD1

piRNA biogenesis protein EXD1 (EXD1) is a protein from Homo sapiens identified by UniProt accession Q8NHP7, 514 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.

Target properties

Protein name	piRNA biogenesis protein EXD1
UniProt accession	Q8NHP7
Gene	EXD1
Organism	Homo sapiens
Length	514 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (69)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.34
systolic blood pressure · score 0.34
body height · score 0.29
creatinine measurement · score 0.26
hematocrit · score 0.26
hypertension · score 0.25
vital capacity · score 0.25
hemoglobin measurement · score 0.24
blood pressure · score 0.23
lean body mass · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NHP7-F1	alphafold	PREDICTED	64.61	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NHP7.

Amino-acid sequence (514 residues)

MEDSEFLAYV ELLDEVEQGS VRAKASSVSL HAERTWMEKM KVEDLNVCEP ASPAPEAPAT SLLNDLKYSP SEEEEVTYTV INQFQQKFGA AILHIKKQNV LSVAAEGANV CRHGKLCWLQ VATNCRVYLF DIFLLGSRAF HNGLQMILED KRILKVIHDC RWLSDCLSHQ YGILLNNVFD TQVADVLQFS METGGYLPNC ITTLQESLIK HLQVAPKYLS FLEKRQKLIQ ENPEVWFIRP VSPSLLKILA LEATYLLPLR LALLDEMMSD LTTLVDGYLN TYREGSADRL GGTEPTCMEL PEELLQLKDF QKQRREKAAR EYRVNAQGLL IRTVLQPKKL VTETAGKEEK VKGFLFGKNF RIDKAPSFTS QDFHGDVNLL KEESLNKQAT NPQHLPPTEE GETSEDSSNK LICTKSKGSE DQRITQKEHF MTPKHEFQAS LSLKEETEQL LMVENKEDLK CTKQAVSMSS FPQETRVSPS DTFYPIRKTV VSTLPPCPAL EKIDSWISPF LNLP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards