Telomere repeats-binding bouquet formation protein…

About Telomere repeats-binding bouquet formation protein 2

Telomere repeats-binding bouquet formation protein 2 (TERB2) is a protein from Homo sapiens identified by UniProt accession Q8NHR7, 220 residues long. MolForge cross-references it against 0 known binders and 134 disease associations.

Target properties

Protein name	Telomere repeats-binding bouquet formation protein 2
UniProt accession	Q8NHR7
Gene	TERB2
Organism	Homo sapiens
Length	220 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (134)

Diseases linked to this target (Open Targets).

spermatogenic failure 59 · score 0.51
male infertility with azoospermia or oligozoospermia due to single gene mutation · score 0.38
azoospermia · score 0.29
drug use measurement · score 0.10
partial chromosome Y deletion · score 0.07
primary ovarian insufficiency · score 0.07
male infertility with teratozoospermia due to single gene mutation · score 0.07
isochromosomy Yp · score 0.07
spermatogenic failure 25 · score 0.07
spermatogenic failures 50 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NHR7-F1	alphafold	PREDICTED	71.44	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NHR7.

Amino-acid sequence (220 residues)

MFQGQRGWFC GSVSQDLRQF WVAEGGTISD PRAADFLFSC DASHPDTLRI YQSLDYIEDN ATVFHAYYLS AVANAKIKNS VALGHFILPP ACLQKEIRRK IGSFIWEQDQ HFLIEKHDEV TPNEIKTLRE NSELATEHKK ELSKSPEKHF IRTPVVEKQM YFPLQNYPVN NMVTGYISID AMKKFLGELH DFIPGTSGYL AYHVQNEINM SAIKNKLKRK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Telomere repeats-binding bouquet formation protein 2 (TERB2)