Profilin-4 (PFN4)
Homo sapiens — UniProt Q8NHR9
Data last refreshed: (UniProt release unknown)
Key facts
Profilin-4 (PFN4) is a protein from Homo sapiens identified by UniProt accession Q8NHR9, 129 residues long. MolForge cross-references it against 0 known binders and 118 disease associations.
- UniProt accession: Q8NHR9; gene symbol PFN4.
- Organism: Homo sapiens.
- Length: 129 amino acids.
- Top disease associations (Open Targets): reticulocyte measurement, azoospermia and male infertility with teratozoospermia due to single gene mutation.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Profilin-4 |
|---|---|
| UniProt accession | Q8NHR9 |
| Gene | PFN4 |
| Organism | Homo sapiens |
| Length | 129 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (118)
Diseases linked to this target (Open Targets).
- reticulocyte measurement · score 0.15
- azoospermia · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- lifestyle measurement · score 0.08
- deafness-infertility syndrome · score 0.08
- spermatogenic failure 65 · score 0.08
- spermatogenic failure 72 · score 0.08
- spermatogenic failure 18 · score 0.08
- spermatogenic failure 46 · score 0.08
- spermatogenic failure 27 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NHR9-F1 | alphafold | PREDICTED | 94.16 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NHR9.
Amino-acid sequence (129 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PFN4?
The strongest Open Targets associations for PFN4 are reticulocyte measurement, azoospermia, male infertility with teratozoospermia due to single gene mutation, lifestyle measurement and deafness-infertility syndrome.
How long is the PFN4 protein?
The Homo sapiens PFN4 protein (UniProt Q8NHR9) is 129 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NHR9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NHR9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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