Claudin domain-containing protein 2 (CLDND2)
Homo sapiens — UniProt Q8NHS1
Data last refreshed: (UniProt release unknown)
Key facts
Claudin domain-containing protein 2 (CLDND2) is a protein from Homo sapiens identified by UniProt accession Q8NHS1, 167 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.
- UniProt accession: Q8NHS1; gene symbol CLDND2.
- Organism: Homo sapiens.
- Length: 167 amino acids.
- Top disease associations (Open Targets): neutrophil count, neutrophil percentage of leukocytes and sum of basophil and neutrophil counts.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Claudin domain-containing protein 2 |
|---|---|
| UniProt accession | Q8NHS1 |
| Gene | CLDND2 |
| Organism | Homo sapiens |
| Length | 167 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (16)
Diseases linked to this target (Open Targets).
- neutrophil count · score 0.06
- neutrophil percentage of leukocytes · score 0.05
- sum of basophil and neutrophil counts · score 0.05
- diabetes mellitus, permanent neonatal 4 · score 0.04
- diabetes mellitus, transient neonatal, 3 · score 0.04
- MODY · score 0.04
- permanent neonatal diabetes mellitus 1 · score 0.04
- granulocyte count · score 0.04
- myeloid white cell count · score 0.03
- hypoparathyroidism, familial isolated, 2 · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NHS1-F1 | alphafold | PREDICTED | 88.68 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NHS1.
Amino-acid sequence (167 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CLDND2?
The strongest Open Targets associations for CLDND2 are neutrophil count, neutrophil percentage of leukocytes, sum of basophil and neutrophil counts, diabetes mellitus, permanent neonatal 4 and diabetes mellitus, transient neonatal, 3.
How long is the CLDND2 protein?
The Homo sapiens CLDND2 protein (UniProt Q8NHS1) is 167 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NHS1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NHS1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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