About Rhox homeobox family member 1
Rhox homeobox family member 1 (RHOXF1) is a protein
from Homo sapiens identified by UniProt accession
Q8NHV9, 184 residues long.
MolForge cross-references it against 0 known binders and
88 disease associations.
Target properties
| Protein name | Rhox homeobox family member 1 |
|---|
| UniProt accession | Q8NHV9 |
|---|
| Gene | RHOXF1 |
|---|
| Organism | Homo sapiens |
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| Length | 184 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (88)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- partial chromosome Y deletion · score 0.08
- spermatogenic failure 8 · score 0.07
- spermatogenic failure 1 · score 0.07
- spermatogenic failure 25 · score 0.07
- spermatogenic failure 48 · score 0.07
- spermatogenic failure 51 · score 0.07
- spermatogenic failure, X-linked, 3 · score 0.07
- spermatogenic failure 40 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NHV9-F1 | alphafold | PREDICTED | 64.27 | — |
Amino-acid sequence (184 residues)
MARSLVHDTV FYCLSVYQVK ISPTPQLGAA SSAEGHVGQG APGLMGNMNP EGGVNHENGM NRDGGMIPEG GGGNQEPRQQ PQPPPEEPAQ AAMEGPQPEN MQPRTRRTKF TLLQVEELES VFRHTQYPDV PTRRELAENL GVTEDKVRVW FKNKRARCRR HQRELMLANE LRADPDDCVY IVVD
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