Rhox homeobox family member 1 (RHOXF1)
Homo sapiens — UniProt Q8NHV9
Data last refreshed: (UniProt release unknown)
Key facts
Rhox homeobox family member 1 (RHOXF1) is a protein from Homo sapiens identified by UniProt accession Q8NHV9, 184 residues long. MolForge cross-references it against 0 known binders and 88 disease associations.
- UniProt accession: Q8NHV9; gene symbol RHOXF1.
- Organism: Homo sapiens.
- Length: 184 amino acids.
- Top disease associations (Open Targets): azoospermia, male infertility with teratozoospermia due to single gene mutation and partial chromosome Y deletion.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Rhox homeobox family member 1 |
|---|---|
| UniProt accession | Q8NHV9 |
| Gene | RHOXF1 |
| Organism | Homo sapiens |
| Length | 184 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (88)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- partial chromosome Y deletion · score 0.08
- spermatogenic failure 8 · score 0.07
- spermatogenic failure 1 · score 0.07
- spermatogenic failure 25 · score 0.07
- spermatogenic failure 48 · score 0.07
- spermatogenic failure 51 · score 0.07
- spermatogenic failure, X-linked, 3 · score 0.07
- spermatogenic failure 40 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NHV9-F1 | alphafold | PREDICTED | 64.27 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NHV9.
Amino-acid sequence (184 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RHOXF1?
The strongest Open Targets associations for RHOXF1 are azoospermia, male infertility with teratozoospermia due to single gene mutation, partial chromosome Y deletion, spermatogenic failure 8 and spermatogenic failure 1.
How long is the RHOXF1 protein?
The Homo sapiens RHOXF1 protein (UniProt Q8NHV9) is 184 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NHV9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NHV9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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