Transcriptional repressor CTCFL (CTCFL)
Homo sapiens — UniProt Q8NI51
Data last refreshed: (UniProt release unknown)
Key facts
Transcriptional repressor CTCFL (CTCFL) is a protein from Homo sapiens identified by UniProt accession Q8NI51, 663 residues long. MolForge cross-references it against 0 known binders and 180 disease associations.
- UniProt accession: Q8NI51; gene symbol CTCFL.
- Organism: Homo sapiens.
- Length: 663 amino acids.
- Top disease associations (Open Targets): triglyceride measurement, FEV/FVC ratio and alkaline phosphatase measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcriptional repressor CTCFL |
|---|---|
| UniProt accession | Q8NI51 |
| Gene | CTCFL |
| Organism | Homo sapiens |
| Length | 663 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (180)
Diseases linked to this target (Open Targets).
- triglyceride measurement · score 0.40
- FEV/FVC ratio · score 0.34
- alkaline phosphatase measurement · score 0.33
- erythrocyte count · score 0.30
- hemoglobin measurement · score 0.27
- reticulocyte count · score 0.26
- physical activity · score 0.12
- cancer · score 0.11
- melanoma · score 0.09
- azoospermia · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NI51-F1 | alphafold | PREDICTED | 54.88 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NI51.
Amino-acid sequence (663 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CTCFL?
The strongest Open Targets associations for CTCFL are triglyceride measurement, FEV/FVC ratio, alkaline phosphatase measurement, erythrocyte count and hemoglobin measurement.
How long is the CTCFL protein?
The Homo sapiens CTCFL protein (UniProt Q8NI51) is 663 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NI51 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NI51 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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