Putative inactive ribonuclease 11 (RNASE11)
Homo sapiens — UniProt Q8TAA1
Data last refreshed: (UniProt release unknown)
Key facts
Putative inactive ribonuclease 11 (RNASE11) is a protein from Homo sapiens identified by UniProt accession Q8TAA1, 199 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.
- UniProt accession: Q8TAA1; gene symbol RNASE11.
- Organism: Homo sapiens.
- Length: 199 amino acids.
- Top disease associations (Open Targets): late-onset Alzheimers disease, Hepatic veno-occlusive disease - immunodeficiency and idiopathic hypereosinophilic syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Putative inactive ribonuclease 11 |
|---|---|
| UniProt accession | Q8TAA1 |
| Gene | RNASE11 |
| Organism | Homo sapiens |
| Length | 199 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (22)
Diseases linked to this target (Open Targets).
- late-onset Alzheimers disease · score 0.14
- Hepatic veno-occlusive disease - immunodeficiency · score 0.04
- idiopathic hypereosinophilic syndrome · score 0.04
- immunodeficiency 75 · score 0.04
- immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias · score 0.03
- Recurrent infections-myelofibrosis-nephromegaly syndrome · score 0.03
- immunodeficiency 76 · score 0.03
- immunodeficiency 80 with or without congenital cardiomyopathy · score 0.03
- autoimmune lymphoproliferative syndrome type 4 · score 0.03
- neutropenia, severe congenital, 9, autosomal dominant · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TAA1-F1 | alphafold | PREDICTED | 55.17 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TAA1.
Amino-acid sequence (199 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RNASE11?
The strongest Open Targets associations for RNASE11 are late-onset Alzheimers disease, Hepatic veno-occlusive disease - immunodeficiency, idiopathic hypereosinophilic syndrome, immunodeficiency 75 and immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias.
How long is the RNASE11 protein?
The Homo sapiens RNASE11 protein (UniProt Q8TAA1) is 199 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TAA1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TAA1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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