Protein phosphatase 1 regulatory subunit 14C (PPP1R14C)
Homo sapiens — UniProt Q8TAE6
Data last refreshed: (UniProt release unknown)
Key facts
Protein phosphatase 1 regulatory subunit 14C (PPP1R14C) is a protein from Homo sapiens identified by UniProt accession Q8TAE6, 165 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.
- UniProt accession: Q8TAE6; gene symbol PPP1R14C.
- Organism: Homo sapiens.
- Length: 165 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, pulmonary embolism and diabetes mellitus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein phosphatase 1 regulatory subunit 14C |
|---|---|
| UniProt accession | Q8TAE6 |
| Gene | PPP1R14C |
| Organism | Homo sapiens |
| Length | 165 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (33)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- pulmonary embolism · score 0.14
- diabetes mellitus · score 0.13
- triple-negative breast cancer · score 0.08
- breast carcinoma · score 0.04
- neoplasm · score 0.03
- Down syndrome · score 0.03
- pachyonychia congenita · score 0.03
- oral squamous cell carcinoma · score 0.01
- severe acute respiratory syndrome · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TAE6-F1 | alphafold | PREDICTED | 62.69 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TAE6.
Amino-acid sequence (165 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PPP1R14C?
The strongest Open Targets associations for PPP1R14C are neurodegenerative disease, pulmonary embolism, diabetes mellitus, triple-negative breast cancer and breast carcinoma.
How long is the PPP1R14C protein?
The Homo sapiens PPP1R14C protein (UniProt Q8TAE6) is 165 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TAE6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TAE6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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