Voltage-gated potassium channel regulatory subunit KCNG3 (KCNG3)
Homo sapiens — UniProt Q8TAE7
Data last refreshed: (UniProt release unknown)
Key facts
Voltage-gated potassium channel regulatory subunit KCNG3 (KCNG3) is a protein from Homo sapiens identified by UniProt accession Q8TAE7, 436 residues long. MolForge cross-references it against 0 known binders and 74 disease associations.
- UniProt accession: Q8TAE7; gene symbol KCNG3.
- Organism: Homo sapiens.
- Length: 436 amino acids.
- Top disease associations (Open Targets): multiple sclerosis, Myasthenia gravis and small cell carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Voltage-gated potassium channel regulatory subunit KCNG3 |
|---|---|
| UniProt accession | Q8TAE7 |
| Gene | KCNG3 |
| Organism | Homo sapiens |
| Length | 436 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (74)
Diseases linked to this target (Open Targets).
- multiple sclerosis · score 0.59
- Myasthenia gravis · score 0.57
- small cell carcinoma · score 0.46
- Muscle weakness · score 0.46
- secondary progressive multiple sclerosis · score 0.43
- anterior ischemic optic neuropathy · score 0.37
- transverse myelitis · score 0.37
- primary progressive multiple sclerosis · score 0.37
- atrial flutter · score 0.35
- atrial fibrillation · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TAE7-F1 | alphafold | PREDICTED | 79.74 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TAE7.
Amino-acid sequence (436 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KCNG3?
The strongest Open Targets associations for KCNG3 are multiple sclerosis, Myasthenia gravis, small cell carcinoma, Muscle weakness and secondary progressive multiple sclerosis.
How long is the KCNG3 protein?
The Homo sapiens KCNG3 protein (UniProt Q8TAE7) is 436 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TAE7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TAE7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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