Large ribosomal subunit protein mL64 (GADD45GIP1)
Homo sapiens — UniProt Q8TAE8
Data last refreshed: (UniProt release unknown)
Key facts
Large ribosomal subunit protein mL64 (GADD45GIP1) is a protein from Homo sapiens identified by UniProt accession Q8TAE8, 222 residues long. MolForge cross-references it against 0 known binders and 73 disease associations.
- UniProt accession: Q8TAE8; gene symbol GADD45GIP1.
- Organism: Homo sapiens.
- Length: 222 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, lysosomal storage disease and erythrocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Large ribosomal subunit protein mL64 |
|---|---|
| UniProt accession | Q8TAE8 |
| Gene | GADD45GIP1 |
| Organism | Homo sapiens |
| Length | 222 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (73)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- lysosomal storage disease · score 0.19
- erythrocyte count · score 0.12
- hypertrichosis · score 0.11
- hepatocellular carcinoma · score 0.10
- neoplasm · score 0.08
- mean corpuscular volume · score 0.08
- mean corpuscular hemoglobin · score 0.07
- acute myeloid leukemia · score 0.04
- triple-negative breast cancer · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TAE8-F1 | alphafold | PREDICTED | 86.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TAE8.
Amino-acid sequence (222 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GADD45GIP1?
The strongest Open Targets associations for GADD45GIP1 are neurodegenerative disease, lysosomal storage disease, erythrocyte count, hypertrichosis and hepatocellular carcinoma.
How long is the GADD45GIP1 protein?
The Homo sapiens GADD45GIP1 protein (UniProt Q8TAE8) is 222 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TAE8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TAE8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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