Oligodendrocyte transcription factor 1 (OLIG1)
Homo sapiens — UniProt Q8TAK6
Data last refreshed: (UniProt release unknown)
Key facts
Oligodendrocyte transcription factor 1 (OLIG1) is a protein from Homo sapiens identified by UniProt accession Q8TAK6, 271 residues long. MolForge cross-references it against 0 known binders and 104 disease associations.
- UniProt accession: Q8TAK6; gene symbol OLIG1.
- Organism: Homo sapiens.
- Length: 271 amino acids.
- Top disease associations (Open Targets): eosinophil count, cortical surface area measurement and eosinophil percentage of leukocytes.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Oligodendrocyte transcription factor 1 |
|---|---|
| UniProt accession | Q8TAK6 |
| Gene | OLIG1 |
| Organism | Homo sapiens |
| Length | 271 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (104)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.40
- cortical surface area measurement · score 0.36
- eosinophil percentage of leukocytes · score 0.35
- alcohol consumption measurement · score 0.29
- brain measurement · score 0.27
- cortical thickness · score 0.27
- eosinophil percentage of granulocytes · score 0.26
- neutrophil percentage of granulocytes · score 0.25
- bitter alcoholic beverage consumption measurement · score 0.24
- alcohol use disorder measurement · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TAK6-F1 | alphafold | PREDICTED | 59.24 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TAK6.
Amino-acid sequence (271 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with OLIG1?
The strongest Open Targets associations for OLIG1 are eosinophil count, cortical surface area measurement, eosinophil percentage of leukocytes, alcohol consumption measurement and brain measurement.
How long is the OLIG1 protein?
The Homo sapiens OLIG1 protein (UniProt Q8TAK6) is 271 amino acids long.
Browse: Targets: O · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TAK6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TAK6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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