Zinc finger protein 420 (ZNF420)
Homo sapiens — UniProt Q8TAQ5
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger protein 420 (ZNF420) is a protein from Homo sapiens identified by UniProt accession Q8TAQ5, 688 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.
- UniProt accession: Q8TAQ5; gene symbol ZNF420.
- Organism: Homo sapiens.
- Length: 688 amino acids.
- Top disease associations (Open Targets): eosinophil count, acute myeloid leukemia and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger protein 420 |
|---|---|
| UniProt accession | Q8TAQ5 |
| Gene | ZNF420 |
| Organism | Homo sapiens |
| Length | 688 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (47)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.28
- acute myeloid leukemia · score 0.25
- breast adenocarcinoma · score 0.25
- body height · score 0.23
- head and neck squamous cell carcinoma · score 0.23
- squamous cell lung carcinoma · score 0.23
- lung adenocarcinoma · score 0.23
- gastric adenocarcinoma · score 0.23
- urinary bladder cancer · score 0.23
- chronic lymphocytic leukemia · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TAQ5-F1 | alphafold | PREDICTED | 77.97 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TAQ5.
Amino-acid sequence (688 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZNF420?
The strongest Open Targets associations for ZNF420 are eosinophil count, acute myeloid leukemia, breast adenocarcinoma, body height and head and neck squamous cell carcinoma.
How long is the ZNF420 protein?
The Homo sapiens ZNF420 protein (UniProt Q8TAQ5) is 688 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TAQ5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TAQ5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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