SUN domain-containing protein 3 (SUN3)

About SUN domain-containing protein 3

SUN domain-containing protein 3 (SUN3) is a protein from Homo sapiens identified by UniProt accession Q8TAQ9, 357 residues long. MolForge cross-references it against 0 known binders and 112 disease associations.

Target properties

Protein name	SUN domain-containing protein 3
UniProt accession	Q8TAQ9
Gene	SUN3
Organism	Homo sapiens
Length	357 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (112)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.32
neutrophil count · score 0.22
leukocyte count · score 0.12
azoospermia · score 0.09
male infertility with teratozoospermia due to single gene mutation · score 0.08
partial chromosome Y deletion · score 0.08
congenital bilateral absence of vas deferens · score 0.06
spermatogenic failure 25 · score 0.06
spermatogenic failure 39 · score 0.06
spermatogenic failure 41 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TAQ9-F1	alphafold	PREDICTED	75.99	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TAQ9.

Amino-acid sequence (357 residues)

MSGKTKARRA AMFFRRCSED ASGSASGNAL LSEDENPDAN GVTRSWKIIL STMLTLTFLL VGLLNHQWLK ETDVPQKSRQ LYAIIAEYGS RLYKYQARLR MPKEQLELLK KESQNLENNF RQILFLIEQI DVLKALLRDM KDGMDNNHNW NTHGDPVEDP DHTEEVSNLV NYVLKKLRED QVEMADYALK SAGASIIEAG TSESYKNNKA KLYWHGIGFL NHEMPPDIIL QPDVYPGKCW AFPGSQGHTL IKLATKIIPT AVTMEHISEK VSPSGNISSA PKEFSVYGIT KKCEGEEIFL GQFIYNKTGT TVQTFELQHA VSEYLLCVKL NIFSNWGHPK YTCLYRFRVH GTPGKHI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards