Gasdermin-B (GSDMB)
Homo sapiens — UniProt Q8TAX9
Data last refreshed: (UniProt release unknown)
Key facts
Gasdermin-B (GSDMB) is a protein from Homo sapiens identified by UniProt accession Q8TAX9, 416 residues long. MolForge cross-references it against 0 known binders and 181 disease associations.
- UniProt accession: Q8TAX9; gene symbol GSDMB.
- Organism: Homo sapiens.
- Length: 416 amino acids.
- Top disease associations (Open Targets): childhood onset asthma, asthma and leukocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Gasdermin-B |
|---|---|
| UniProt accession | Q8TAX9 |
| Gene | GSDMB |
| Organism | Homo sapiens |
| Length | 416 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (181)
Diseases linked to this target (Open Targets).
- childhood onset asthma · score 0.32
- asthma · score 0.32
- leukocyte count · score 0.31
- neutrophil count · score 0.28
- allergic disease · score 0.27
- allergic asthma · score 0.26
- lymphocyte count · score 0.24
- type 1 diabetes mellitus · score 0.24
- age at onset · score 0.24
- pneumonia · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TAX9-F1 | alphafold | PREDICTED | 71.54 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TAX9.
Amino-acid sequence (416 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GSDMB?
The strongest Open Targets associations for GSDMB are childhood onset asthma, asthma, leukocyte count, neutrophil count and allergic disease.
How long is the GSDMB protein?
The Homo sapiens GSDMB protein (UniProt Q8TAX9) is 416 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TAX9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TAX9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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