Ganglioside-induced differentiation-associated protein 1 (GDAP1)
Homo sapiens — UniProt Q8TB36
Data last refreshed: (UniProt release unknown)
Key facts
Ganglioside-induced differentiation-associated protein 1 (GDAP1) is a protein from Homo sapiens identified by UniProt accession Q8TB36, 358 residues long. MolForge cross-references it against 0 known binders and 130 disease associations.
- UniProt accession: Q8TB36; gene symbol GDAP1.
- Organism: Homo sapiens.
- Length: 358 amino acids.
- Top disease associations (Open Targets): Autosomal recessive Charcot-Marie-Tooth disease with hoarseness, Charcot-Marie-Tooth disease type 4A and Charcot-Marie-Tooth disease axonal type 2K.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ganglioside-induced differentiation-associated protein 1 |
|---|---|
| UniProt accession | Q8TB36 |
| Gene | GDAP1 |
| Organism | Homo sapiens |
| Length | 358 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (130)
Diseases linked to this target (Open Targets).
- Autosomal recessive Charcot-Marie-Tooth disease with hoarseness · score 0.83
- Charcot-Marie-Tooth disease type 4A · score 0.81
- Charcot-Marie-Tooth disease axonal type 2K · score 0.81
- Charcot-Marie-Tooth disease recessive intermediate A · score 0.74
- Autosomal recessive intermediate Charcot-Marie-Tooth disease type A · score 0.69
- Charcot-Marie-Tooth disease · score 0.66
- genetic disorder · score 0.52
- peripheral neuropathy · score 0.45
- autosomal dominant Charcot-Marie-Tooth disease type 2K · score 0.41
- Sensory neuropathy · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TB36-F1 | alphafold | PREDICTED | 87.29 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TB36.
Amino-acid sequence (358 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GDAP1?
The strongest Open Targets associations for GDAP1 are Autosomal recessive Charcot-Marie-Tooth disease with hoarseness, Charcot-Marie-Tooth disease type 4A, Charcot-Marie-Tooth disease axonal type 2K, Charcot-Marie-Tooth disease recessive intermediate A and Autosomal recessive intermediate Charcot-Marie-Tooth disease type A.
How long is the GDAP1 protein?
The Homo sapiens GDAP1 protein (UniProt Q8TB36) is 358 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TB36 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TB36 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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