Iron-sulfur cluster transfer protein NUBPL (NUBPL)

About Iron-sulfur cluster transfer protein NUBPL

Iron-sulfur cluster transfer protein NUBPL (NUBPL) is a protein from Homo sapiens identified by UniProt accession Q8TB37, 319 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.

Target properties

Protein name	Iron-sulfur cluster transfer protein NUBPL
UniProt accession	Q8TB37
Gene	NUBPL
Organism	Homo sapiens
Length	319 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (57)

Diseases linked to this target (Open Targets).

mitochondrial complex I deficiency · score 0.77
neurodegenerative disease · score 0.53
genetic disorder · score 0.48
lymphocyte count · score 0.31
obsessive-compulsive disorder · score 0.27
Tourette syndrome · score 0.27
mitochondrial oxidative phosphorylation disorder · score 0.27
diffuse plaque measurement · score 0.19
Leigh syndrome · score 0.18
colorectal carcinoma · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TB37-F1	alphafold	PREDICTED	84.84	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TB37.

Amino-acid sequence (319 residues)

MGIWQRLLLF GGVSLRAGGG ATAPLGGSRA MVCGRQLSGA GSETLKQRRT QIMSRGLPKQ KPIEGVKQVI VVASGKGGVG KSTTAVNLAL ALAANDSSKA IGLLDVDVYG PSVPKMMNLK GNPELSQSNL MRPLLNYGIA CMSMGFLVEE SEPVVWRGLM VMSAIEKLLR QVDWGQLDYL VVDMPPGTGD VQLSVSQNIP ITGAVIVSTP QDIALMDAHK GAEMFRRVHV PVLGLVQNMS VFQCPKCKHK THIFGADGAR KLAQTLGLEV LGDIPLHLNI REASDTGQPI VFSQPESDEA KAYLRIAVEV VRRLPSPSE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards