Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2)
Homo sapiens — UniProt Q8TB61
Data last refreshed: (UniProt release unknown)
Key facts
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) is a protein from Homo sapiens identified by UniProt accession Q8TB61, 432 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.
- UniProt accession: Q8TB61; gene symbol SLC35B2.
- Organism: Homo sapiens.
- Length: 432 amino acids.
- Target class: Transporter.
- Top disease associations (Open Targets): leukodystrophy, hypomyelinating, 26, with chondrodysplasia, primary bone dysplasia with multiple joint dislocations and scoliosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Adenosine 3'-phospho 5'-phosphosulfate transporter 1 |
|---|---|
| UniProt accession | Q8TB61 |
| Gene | SLC35B2 |
| Organism | Homo sapiens |
| Length | 432 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Transporter (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (58)
Diseases linked to this target (Open Targets).
- leukodystrophy, hypomyelinating, 26, with chondrodysplasia · score 0.52
- primary bone dysplasia with multiple joint dislocations · score 0.33
- scoliosis · score 0.25
- Abnormal corpus callosum morphology · score 0.25
- Cerebral atrophy · score 0.25
- Abnormality of the amniotic fluid · score 0.25
- Short long bone · score 0.25
- Abnormality of the skeletal system · score 0.25
- Intellectual disability · score 0.25
- CNS hypomyelination · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TB61-F1 | alphafold | PREDICTED | 80.92 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TB61.
Amino-acid sequence (432 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC35B2?
The strongest Open Targets associations for SLC35B2 are leukodystrophy, hypomyelinating, 26, with chondrodysplasia, primary bone dysplasia with multiple joint dislocations, scoliosis, Abnormal corpus callosum morphology and Cerebral atrophy.
How long is the SLC35B2 protein?
The Homo sapiens SLC35B2 protein (UniProt Q8TB61) is 432 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TB61 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TB61 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.