3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic (HMGCLL1)
Homo sapiens — UniProt Q8TB92
Data last refreshed: (UniProt release unknown)
Key facts
3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic (HMGCLL1) is a protein from Homo sapiens identified by UniProt accession Q8TB92, 370 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.
- UniProt accession: Q8TB92; gene symbol HMGCLL1.
- Organism: Homo sapiens.
- Length: 370 amino acids.
- Top disease associations (Open Targets): heel bone mineral density, mean corpuscular volume and mean corpuscular hemoglobin concentration.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic |
|---|---|
| UniProt accession | Q8TB92 |
| Gene | HMGCLL1 |
| Organism | Homo sapiens |
| Length | 370 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (28)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.46
- mean corpuscular volume · score 0.43
- mean corpuscular hemoglobin concentration · score 0.41
- mean corpuscular hemoglobin · score 0.40
- blood protein measurement · score 0.40
- neurofibrillary tangles measurement · score 0.34
- glomerular filtration rate · score 0.33
- venous thromboembolism · score 0.32
- bone quantitative ultrasound measurement · score 0.26
- bone density · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TB92-F1 | alphafold | PREDICTED | 84.66 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TB92.
Amino-acid sequence (370 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HMGCLL1?
The strongest Open Targets associations for HMGCLL1 are heel bone mineral density, mean corpuscular volume, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin and blood protein measurement.
How long is the HMGCLL1 protein?
The Homo sapiens HMGCLL1 protein (UniProt Q8TB92) is 370 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TB92 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TB92 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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