T-cell immunomodulatory protein (ITFG1)
Homo sapiens — UniProt Q8TB96
Data last refreshed: (UniProt release unknown)
Key facts
T-cell immunomodulatory protein (ITFG1) is a protein from Homo sapiens identified by UniProt accession Q8TB96, 612 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.
- UniProt accession: Q8TB96; gene symbol ITFG1.
- Organism: Homo sapiens.
- Length: 612 amino acids.
- Top disease associations (Open Targets): Glycogen storage disease due to phosphorylase kinase deficiency, glycogen storage disease IXb and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | T-cell immunomodulatory protein |
|---|---|
| UniProt accession | Q8TB96 |
| Gene | ITFG1 |
| Organism | Homo sapiens |
| Length | 612 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (29)
Diseases linked to this target (Open Targets).
- Glycogen storage disease due to phosphorylase kinase deficiency · score 0.27
- glycogen storage disease IXb · score 0.20
- genetic disorder · score 0.16
- Red cell distribution width · score 0.12
- sex hormone-binding globulin measurement · score 0.09
- platelet crit · score 0.07
- alkaline phosphatase measurement · score 0.06
- hemoglobin measurement · score 0.04
- response to fenofibrate · score 0.02
- total cholesterol change measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TB96-F1 | alphafold | PREDICTED | 89.50 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TB96.
Amino-acid sequence (612 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ITFG1?
The strongest Open Targets associations for ITFG1 are Glycogen storage disease due to phosphorylase kinase deficiency, glycogen storage disease IXb, genetic disorder, Red cell distribution width and sex hormone-binding globulin measurement.
How long is the ITFG1 protein?
The Homo sapiens ITFG1 protein (UniProt Q8TB96) is 612 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TB96 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TB96 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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