THAP domain-containing protein 6 (THAP6)
Homo sapiens — UniProt Q8TBB0
Data last refreshed: (UniProt release unknown)
Key facts
THAP domain-containing protein 6 (THAP6) is a protein from Homo sapiens identified by UniProt accession Q8TBB0, 222 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.
- UniProt accession: Q8TBB0; gene symbol THAP6.
- Organism: Homo sapiens.
- Length: 222 amino acids.
- Top disease associations (Open Targets): platelet count, mean platelet volume and FEV/FVC ratio.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | THAP domain-containing protein 6 |
|---|---|
| UniProt accession | Q8TBB0 |
| Gene | THAP6 |
| Organism | Homo sapiens |
| Length | 222 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (10)
Diseases linked to this target (Open Targets).
- platelet count · score 0.39
- mean platelet volume · score 0.34
- FEV/FVC ratio · score 0.23
- self reported educational attainment · score 0.15
- calcium measurement · score 0.03
- C-X-C motif chemokine 10 measurement · score 0.03
- chronic kidney disease · score 0.01
- breast carcinoma · score 0.00
- type 1 diabetes mellitus · score 0.00
- squamous cell carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TBB0-F1 | alphafold | PREDICTED | 73.30 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TBB0.
Amino-acid sequence (222 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with THAP6?
The strongest Open Targets associations for THAP6 are platelet count, mean platelet volume, FEV/FVC ratio, self reported educational attainment and calcium measurement.
How long is the THAP6 protein?
The Homo sapiens THAP6 protein (UniProt Q8TBB0) is 222 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TBB0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TBB0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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