E3 ubiquitin-protein ligase LNX (LNX1)
Homo sapiens — UniProt Q8TBB1
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase LNX (LNX1) is a protein from Homo sapiens identified by UniProt accession Q8TBB1, 728 residues long. MolForge cross-references it against 0 known binders and 106 disease associations.
- UniProt accession: Q8TBB1; gene symbol LNX1.
- Organism: Homo sapiens.
- Length: 728 amino acids.
- Top disease associations (Open Targets): type 2 diabetes mellitus, uterine fibroid and balding measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase LNX |
|---|---|
| UniProt accession | Q8TBB1 |
| Gene | LNX1 |
| Organism | Homo sapiens |
| Length | 728 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (106)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.45
- uterine fibroid · score 0.43
- balding measurement · score 0.40
- body mass index · score 0.38
- FEV/FVC ratio · score 0.37
- cervical artery dissection · score 0.33
- diffuse plaque measurement · score 0.33
- lobe attachment · score 0.33
- facial hair thickness measurement · score 0.32
- serum albumin measurement · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TBB1-F1 | alphafold | PREDICTED | 71.79 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TBB1.
Amino-acid sequence (728 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LNX1?
The strongest Open Targets associations for LNX1 are type 2 diabetes mellitus, uterine fibroid, balding measurement, body mass index and FEV/FVC ratio.
How long is the LNX1 protein?
The Homo sapiens LNX1 protein (UniProt Q8TBB1) is 728 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TBB1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TBB1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.