Kelch domain-containing protein 4 (KLHDC4)
Homo sapiens — UniProt Q8TBB5
Data last refreshed: (UniProt release unknown)
Key facts
Kelch domain-containing protein 4 (KLHDC4) is a protein from Homo sapiens identified by UniProt accession Q8TBB5, 520 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.
- UniProt accession: Q8TBB5; gene symbol KLHDC4.
- Organism: Homo sapiens.
- Length: 520 amino acids.
- Top disease associations (Open Targets): Cleft palate, hair colour measurement and neoplasm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Kelch domain-containing protein 4 |
|---|---|
| UniProt accession | Q8TBB5 |
| Gene | KLHDC4 |
| Organism | Homo sapiens |
| Length | 520 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (14)
Diseases linked to this target (Open Targets).
- Cleft palate · score 0.26
- hair colour measurement · score 0.13
- neoplasm · score 0.05
- platelet crit · score 0.05
- type 2 diabetes mellitus · score 0.04
- eye measurement · score 0.03
- cancer · score 0.03
- mean corpuscular hemoglobin concentration · score 0.02
- psoriasis · score 0.01
- metabolic syndrome · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TBB5-F1 | alphafold | PREDICTED | 80.35 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TBB5.
Amino-acid sequence (520 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KLHDC4?
The strongest Open Targets associations for KLHDC4 are Cleft palate, hair colour measurement, neoplasm, platelet crit and type 2 diabetes mellitus.
How long is the KLHDC4 protein?
The Homo sapiens KLHDC4 protein (UniProt Q8TBB5) is 520 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TBB5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TBB5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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