Zinc finger CCHC-type and RNA-binding motif-containing protein 1 (ZCRB1)
Homo sapiens — UniProt Q8TBF4
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger CCHC-type and RNA-binding motif-containing protein 1 (ZCRB1) is a protein from Homo sapiens identified by UniProt accession Q8TBF4, 217 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.
- UniProt accession: Q8TBF4; gene symbol ZCRB1.
- Organism: Homo sapiens.
- Length: 217 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, COVID-19 and severe acute respiratory syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger CCHC-type and RNA-binding motif-containing protein 1 |
|---|---|
| UniProt accession | Q8TBF4 |
| Gene | ZCRB1 |
| Organism | Homo sapiens |
| Length | 217 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (22)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- COVID-19 · score 0.37
- severe acute respiratory syndrome · score 0.37
- acute myeloid leukemia · score 0.25
- blood urea nitrogen measurement · score 0.22
- serum urea measurement · score 0.19
- appendicular lean mass · score 0.18
- cystatin C measurement · score 0.16
- diastolic blood pressure · score 0.14
- urate measurement · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TBF4-F1 | alphafold | PREDICTED | 74.47 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TBF4.
Amino-acid sequence (217 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZCRB1?
The strongest Open Targets associations for ZCRB1 are neurodegenerative disease, COVID-19, severe acute respiratory syndrome, acute myeloid leukemia and blood urea nitrogen measurement.
How long is the ZCRB1 protein?
The Homo sapiens ZCRB1 protein (UniProt Q8TBF4) is 217 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TBF4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TBF4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.