GPI alpha-1,4-mannosyltransferase I, stabilizing subunit (PIGX)
Homo sapiens — UniProt Q8TBF5
Data last refreshed: (UniProt release unknown)
Key facts
GPI alpha-1,4-mannosyltransferase I, stabilizing subunit (PIGX) is a protein from Homo sapiens identified by UniProt accession Q8TBF5, 258 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.
- UniProt accession: Q8TBF5; gene symbol PIGX.
- Organism: Homo sapiens.
- Length: 258 amino acids.
- Top disease associations (Open Targets): seizures, early-onset, with neurodegeneration and brain calcifications, obesity due to CEP19 deficiency and morbid obesity.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | GPI alpha-1,4-mannosyltransferase I, stabilizing subunit |
|---|---|
| UniProt accession | Q8TBF5 |
| Gene | PIGX |
| Organism | Homo sapiens |
| Length | 258 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (34)
Diseases linked to this target (Open Targets).
- seizures, early-onset, with neurodegeneration and brain calcifications · score 0.52
- obesity due to CEP19 deficiency · score 0.36
- morbid obesity · score 0.36
- Bardet-Biedl syndrome · score 0.33
- neurodegenerative disease · score 0.31
- eosinophil count · score 0.27
- asthma · score 0.26
- Eczematoid dermatitis · score 0.24
- eosinophil percentage of leukocytes · score 0.22
- allergic disease · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TBF5-F1 | alphafold | PREDICTED | 84.28 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TBF5.
Amino-acid sequence (258 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PIGX?
The strongest Open Targets associations for PIGX are seizures, early-onset, with neurodegeneration and brain calcifications, obesity due to CEP19 deficiency, morbid obesity, Bardet-Biedl syndrome and neurodegenerative disease.
How long is the PIGX protein?
The Homo sapiens PIGX protein (UniProt Q8TBF5) is 258 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TBF5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TBF5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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