Ethanolamine-phosphate phospho-lyase (ETNPPL)
Homo sapiens — UniProt Q8TBG4
Data last refreshed: (UniProt release unknown)
Key facts
Ethanolamine-phosphate phospho-lyase (ETNPPL) is a protein from Homo sapiens identified by UniProt accession Q8TBG4, 499 residues long. MolForge cross-references it against 0 known binders and 155 disease associations.
- UniProt accession: Q8TBG4; gene symbol ETNPPL.
- Organism: Homo sapiens.
- Length: 499 amino acids.
- Top disease associations (Open Targets): glomerular filtration rate, creatinine measurement and glioblastoma multiforme.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ethanolamine-phosphate phospho-lyase |
|---|---|
| UniProt accession | Q8TBG4 |
| Gene | ETNPPL |
| Organism | Homo sapiens |
| Length | 499 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (155)
Diseases linked to this target (Open Targets).
- glomerular filtration rate · score 0.38
- creatinine measurement · score 0.27
- glioblastoma multiforme · score 0.20
- breast adenocarcinoma · score 0.18
- hepatocellular carcinoma · score 0.08
- benign adult familial myoclonic epilepsy · score 0.07
- Hypomaturation amelogenesis imperfecta · score 0.07
- essential tremor · score 0.06
- familial hypobetalipoproteinemia 2 · score 0.06
- Hypoplastic amelogenesis imperfecta · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TBG4-F1 | alphafold | PREDICTED | 89.95 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TBG4.
Amino-acid sequence (499 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ETNPPL?
The strongest Open Targets associations for ETNPPL are glomerular filtration rate, creatinine measurement, glioblastoma multiforme, breast adenocarcinoma and hepatocellular carcinoma.
How long is the ETNPPL protein?
The Homo sapiens ETNPPL protein (UniProt Q8TBG4) is 499 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TBG4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TBG4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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