Arrestin domain-containing protein 2 (ARRDC2)
Homo sapiens — UniProt Q8TBH0
Data last refreshed: (UniProt release unknown)
Key facts
Arrestin domain-containing protein 2 (ARRDC2) is a protein from Homo sapiens identified by UniProt accession Q8TBH0, 407 residues long. MolForge cross-references it against 0 known binders and 127 disease associations.
- UniProt accession: Q8TBH0; gene symbol ARRDC2.
- Organism: Homo sapiens.
- Length: 407 amino acids.
- Top disease associations (Open Targets): monocyte count, lymphocyte count and body height.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Arrestin domain-containing protein 2 |
|---|---|
| UniProt accession | Q8TBH0 |
| Gene | ARRDC2 |
| Organism | Homo sapiens |
| Length | 407 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (127)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.42
- lymphocyte count · score 0.41
- body height · score 0.39
- monocyte percentage of leukocytes · score 0.38
- heel bone mineral density · score 0.38
- appendicular lean mass · score 0.35
- neutrophil percentage of leukocytes · score 0.33
- lymphocyte percentage of leukocytes · score 0.32
- lean body mass · score 0.27
- fat body mass · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TBH0-F1 | alphafold | PREDICTED | 81.79 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TBH0.
Amino-acid sequence (407 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARRDC2?
The strongest Open Targets associations for ARRDC2 are monocyte count, lymphocyte count, body height, monocyte percentage of leukocytes and heel bone mineral density.
How long is the ARRDC2 protein?
The Homo sapiens ARRDC2 protein (UniProt Q8TBH0) is 407 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TBH0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TBH0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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