Phospholipid phosphatase-related protein type 1 (PLPPR1)
Homo sapiens — UniProt Q8TBJ4
Data last refreshed: (UniProt release unknown)
Key facts
Phospholipid phosphatase-related protein type 1 (PLPPR1) is a protein from Homo sapiens identified by UniProt accession Q8TBJ4, 325 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.
- UniProt accession: Q8TBJ4; gene symbol PLPPR1.
- Organism: Homo sapiens.
- Length: 325 amino acids.
- Top disease associations (Open Targets): body height, Parkinson disease and age at diagnosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Phospholipid phosphatase-related protein type 1 |
|---|---|
| UniProt accession | Q8TBJ4 |
| Gene | PLPPR1 |
| Organism | Homo sapiens |
| Length | 325 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (30)
Diseases linked to this target (Open Targets).
- body height · score 0.44
- Parkinson disease · score 0.34
- age at diagnosis · score 0.33
- infectious disease · score 0.22
- low grade glioma · score 0.12
- breast adenocarcinoma · score 0.10
- prostate adenocarcinoma · score 0.10
- lung adenocarcinoma · score 0.10
- protein measurement · score 0.09
- clear cell renal carcinoma · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TBJ4-F1 | alphafold | PREDICTED | 78.85 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TBJ4.
Amino-acid sequence (325 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLPPR1?
The strongest Open Targets associations for PLPPR1 are body height, Parkinson disease, age at diagnosis, infectious disease and low grade glioma.
How long is the PLPPR1 protein?
The Homo sapiens PLPPR1 protein (UniProt Q8TBJ4) is 325 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TBJ4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TBJ4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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