Fez family zinc finger protein 2 (FEZF2)
Homo sapiens — UniProt Q8TBJ5
Data last refreshed: (UniProt release unknown)
Key facts
Fez family zinc finger protein 2 (FEZF2) is a protein from Homo sapiens identified by UniProt accession Q8TBJ5, 459 residues long. MolForge cross-references it against 0 known binders and 77 disease associations.
- UniProt accession: Q8TBJ5; gene symbol FEZF2.
- Organism: Homo sapiens.
- Length: 459 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, body mass index and age at first sexual intercourse measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Fez family zinc finger protein 2 |
|---|---|
| UniProt accession | Q8TBJ5 |
| Gene | FEZF2 |
| Organism | Homo sapiens |
| Length | 459 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (77)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.49
- body mass index · score 0.30
- age at first sexual intercourse measurement · score 0.27
- body fat percentage · score 0.16
- self reported educational attainment · score 0.16
- fat body mass · score 0.15
- lean body mass · score 0.15
- mathematical ability · score 0.14
- brain volume measurement · score 0.12
- waist circumference · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TBJ5-F1 | alphafold | PREDICTED | 54.03 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TBJ5.
Amino-acid sequence (459 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FEZF2?
The strongest Open Targets associations for FEZF2 are neurodegenerative disease, body mass index, age at first sexual intercourse measurement, body fat percentage and self reported educational attainment.
How long is the FEZF2 protein?
The Homo sapiens FEZF2 protein (UniProt Q8TBJ5) is 459 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TBJ5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TBJ5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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