N-lysine methyltransferase SETD6 (SETD6)
Homo sapiens — UniProt Q8TBK2
Data last refreshed: (UniProt release unknown)
Key facts
N-lysine methyltransferase SETD6 (SETD6) is a protein from Homo sapiens identified by UniProt accession Q8TBK2, 473 residues long. MolForge cross-references it against 0 known binders and 99 disease associations.
- UniProt accession: Q8TBK2; gene symbol SETD6.
- Organism: Homo sapiens.
- Length: 473 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, serum alanine aminotransferase measurement and sex hormone-binding globulin measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | N-lysine methyltransferase SETD6 |
|---|---|
| UniProt accession | Q8TBK2 |
| Gene | SETD6 |
| Organism | Homo sapiens |
| Length | 473 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (99)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.21
- serum alanine aminotransferase measurement · score 0.19
- sex hormone-binding globulin measurement · score 0.18
- alkaline phosphatase measurement · score 0.16
- C-reactive protein measurement · score 0.14
- genetic disorder · score 0.12
- serum gamma-glutamyl transferase measurement · score 0.12
- schizophrenia · score 0.10
- platelet count · score 0.10
- clear cell renal carcinoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TBK2-F1 | alphafold | PREDICTED | 88.74 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TBK2.
Amino-acid sequence (473 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SETD6?
The strongest Open Targets associations for SETD6 are neurodegenerative disease, serum alanine aminotransferase measurement, sex hormone-binding globulin measurement, alkaline phosphatase measurement and C-reactive protein measurement.
How long is the SETD6 protein?
The Homo sapiens SETD6 protein (UniProt Q8TBK2) is 473 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TBK2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TBK2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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