TBC1 domain family member 16 (TBC1D16)

About TBC1 domain family member 16

TBC1 domain family member 16 (TBC1D16) is a protein from Homo sapiens identified by UniProt accession Q8TBP0, 767 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.

Target properties

Protein name	TBC1 domain family member 16
UniProt accession	Q8TBP0
Gene	TBC1D16
Organism	Homo sapiens
Length	767 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (60)

Diseases linked to this target (Open Targets).

total blood protein measurement · score 0.42
lymphocyte count · score 0.40
serum non-albumin protein measurement · score 0.39
cortical surface area measurement · score 0.31
brain measurement · score 0.31
age at menarche · score 0.31
albumin:globulin ratio measurement · score 0.31
blood protein measurement · score 0.30
type 2 diabetes mellitus · score 0.17
mean reticulocyte volume · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TBP0-F1	alphafold	PREDICTED	68.58	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TBP0.

Amino-acid sequence (767 residues)

MSLGRLLRRA SSKASDLLTL TPGGSGSGSP SVLDGEIIYS KNNVCVHPPE GLQGLGEHHP GYLCLYMEKD EMLGATLILA WVPNSRIQRQ DEEALRYITP ESSPVRKAPR PRGRRTRSSG ASHQPSPTEL RPTLTPKDED ILVVAQSVPD RMLASPAPED EEKLAQGLGV DGAQPASQPA CSPSGILSTV SPQDVTEEGR EPRPEAGEED GSLELSAEGV SRDSSFDSDS DTFSSPFCLS PISAALAESR GSVFLESDSS PPSSSDAGLR FPDSNGLLQT PRWDEPQRVC ALEQICGVFR VDLGHMRSLR LFFSDEACTS GQLVVASRES QYKVFHFHHG GLDKLSDVFQ QWKYCTEMQL KDQQVAPDKT CMQFSIRRPK LPSSETHPEE SMYKRLGVSA WLNHLNELGQ VEEEYKLRKA IFFGGIDVSI RGEVWPFLLR YYSHESTSEE REALRLQKRK EYSEIQQKRL SMTPEEHRAF WRNVQFTVDK DVVRTDRNNQ FFRGEDNPNV ESMRRILLNY AVYNPAVGYS QGMSDLVAPI LAEVLDESDT FWCFVGLMQN TIFVSSPRDE DMEKQLLYLR ELLRLTHVRF YQHLVSLGED GLQMLFCHRW LLLCFKREFP EAEALRIWEA CWAHYQTDYF HLFICVAIVA IYGDDVIEQQ LATDQMLLHF GNLAMHMNGE LVLRKARSLL YQFRLLPRIP CSLHDLCKLC GSGMWDSGSM PAVECTGHHP GSESCPYGGT VEMPSPKSLR EGKKGPKTPQ DGFGFRR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards