Membrane protein FAM174A (FAM174A)
Homo sapiens — UniProt Q8TBP5
Data last refreshed: (UniProt release unknown)
Key facts
Membrane protein FAM174A (FAM174A) is a protein from Homo sapiens identified by UniProt accession Q8TBP5, 190 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.
- UniProt accession: Q8TBP5; gene symbol FAM174A.
- Organism: Homo sapiens.
- Length: 190 amino acids.
- Top disease associations (Open Targets): heel bone mineral density, neutrophil count and leukocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Membrane protein FAM174A |
|---|---|
| UniProt accession | Q8TBP5 |
| Gene | FAM174A |
| Organism | Homo sapiens |
| Length | 190 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (18)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.38
- neutrophil count · score 0.33
- leukocyte count · score 0.31
- bone density · score 0.23
- myeloid white cell count · score 0.10
- lymphocyte count · score 0.03
- systemic lupus erythematosus · score 0.03
- monocyte count · score 0.02
- Abnormal sperm morphology · score 0.01
- Sepsis · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TBP5-F1 | alphafold | PREDICTED | 59.04 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TBP5.
Amino-acid sequence (190 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FAM174A?
The strongest Open Targets associations for FAM174A are heel bone mineral density, neutrophil count, leukocyte count, bone density and myeloid white cell count.
How long is the FAM174A protein?
The Homo sapiens FAM174A protein (UniProt Q8TBP5) is 190 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TBP5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TBP5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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