tRNA methyltransferase 10 homolog A (TRMT10A)
Homo sapiens — UniProt Q8TBZ6
Data last refreshed: (UniProt release unknown)
Key facts
tRNA methyltransferase 10 homolog A (TRMT10A) is a protein from Homo sapiens identified by UniProt accession Q8TBZ6, 339 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.
- UniProt accession: Q8TBZ6; gene symbol TRMT10A.
- Organism: Homo sapiens.
- Length: 339 amino acids.
- Top disease associations (Open Targets): primary microcephaly-mild intellectual disability-young-onset diabetes syndrome, genetic disorder and autosomal recessive non-syndromic intellectual disability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | tRNA methyltransferase 10 homolog A |
|---|---|
| UniProt accession | Q8TBZ6 |
| Gene | TRMT10A |
| Organism | Homo sapiens |
| Length | 339 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (64)
Diseases linked to this target (Open Targets).
- primary microcephaly-mild intellectual disability-young-onset diabetes syndrome · score 0.71
- genetic disorder · score 0.47
- autosomal recessive non-syndromic intellectual disability · score 0.46
- Primary microcephaly · score 0.37
- Abnormality of the nervous system · score 0.27
- serum alanine aminotransferase measurement · score 0.17
- body height · score 0.13
- platelet component distribution width · score 0.13
- aspartate aminotransferase measurement · score 0.13
- high density lipoprotein cholesterol measurement · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TBZ6-F1 | alphafold | PREDICTED | 76.07 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TBZ6.
Amino-acid sequence (339 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TRMT10A?
The strongest Open Targets associations for TRMT10A are primary microcephaly-mild intellectual disability-young-onset diabetes syndrome, genetic disorder, autosomal recessive non-syndromic intellectual disability, Primary microcephaly and Abnormality of the nervous system.
How long is the TRMT10A protein?
The Homo sapiens TRMT10A protein (UniProt Q8TBZ6) is 339 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TBZ6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TBZ6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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