Leucine-rich repeat-containing protein 20 (LRRC20)

About Leucine-rich repeat-containing protein 20

Leucine-rich repeat-containing protein 20 (LRRC20) is a protein from Homo sapiens identified by UniProt accession Q8TCA0, 184 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.

Target properties

Protein name	Leucine-rich repeat-containing protein 20
UniProt accession	Q8TCA0
Gene	LRRC20
Organism	Homo sapiens
Length	184 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (11)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.42
blood protein measurement · score 0.29
brain connectivity measurement · score 0.21
body height · score 0.21
esophageal squamous cell carcinoma · score 0.03
IGF-1 measurement · score 0.02
psoriasis · score 0.01
acute quadriplegic myopathy · score 0.01
neoplasm · score 0.01
Systemic lupus erythematosus · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TCA0-F1	alphafold	PREDICTED	94.50	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TCA0.

Amino-acid sequence (184 residues)

MLKKMGEAVA RVARKVNETV ESGSDTLDLA ECKLVSFPIG IYKVLRNVSG QIHLITLANN ELKSLTSKFM TTFSQLRELH LEGNFLHRLP SEVSALQHLK AIDLSRNQFQ DFPEQLTALP ALETINLEEN EIVDVPVEKL AAMPALRSIN LRFNPLNAEV RVIAPPLIKF DMLMSPEGAR APLP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards