Mitogen-activated protein kinase 15 (MAPK15)
Homo sapiens — UniProt Q8TD08
Data last refreshed: (UniProt release unknown)
Key facts
Mitogen-activated protein kinase 15 (MAPK15) is a protein from Homo sapiens identified by UniProt accession Q8TD08, 544 residues long. MolForge cross-references it against 6 known binders and 93 disease associations.
- UniProt accession: Q8TD08; gene symbol MAPK15.
- Organism: Homo sapiens.
- Length: 544 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, osteosarcoma and lung adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mitogen-activated protein kinase 15 |
|---|---|
| UniProt accession | Q8TD08 |
| Gene | MAPK15 |
| Organism | Homo sapiens |
| Length | 544 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (93)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- osteosarcoma · score 0.07
- lung adenocarcinoma · score 0.07
- neoplasm · score 0.07
- Granular Cell Tumor · score 0.06
- Griscelli syndrome type 3 · score 0.06
- attention deficit hyperactivity disorder · score 0.06
- Griscelli disease · score 0.05
- Griscelli disease type 3 · score 0.05
- insulin resistance · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TD08-F1 | alphafold | PREDICTED | 68.08 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TD08.
Amino-acid sequence (544 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MAPK15?
The strongest Open Targets associations for MAPK15 are neurodegenerative disease, osteosarcoma, lung adenocarcinoma, neoplasm and Granular Cell Tumor.
How long is the MAPK15 protein?
The Homo sapiens MAPK15 protein (UniProt Q8TD08) is 544 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TD08 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TD08 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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