Cell surface glycoprotein CD200 receptor 1 (CD200R1)

About Cell surface glycoprotein CD200 receptor 1

Cell surface glycoprotein CD200 receptor 1 (CD200R1) is a protein from Homo sapiens identified by UniProt accession Q8TD46, 348 residues long. MolForge cross-references it against 0 known binders and 221 disease associations.

Target properties

Protein name	Cell surface glycoprotein CD200 receptor 1
UniProt accession	Q8TD46
Gene	CD200R1
Organism	Homo sapiens
Length	348 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (221)

Diseases linked to this target (Open Targets).

eosinophil count · score 0.41
blood protein measurement · score 0.39
asthma · score 0.38
Eczematoid dermatitis · score 0.32
neurodegenerative disease · score 0.30
PHF-tau measurement · score 0.28
sum of eosinophil and basophil counts · score 0.27
lymphocyte count · score 0.26
eosinophil percentage of leukocytes · score 0.21
neutrophil percentage of granulocytes · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TD46-F1	alphafold	PREDICTED	74.53	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TD46.

Amino-acid sequence (348 residues)

MLCPWRTANL GLLLILTIFL VAEAEGAAQP NNSLMLQTSK ENHALASSSL CMDEKQITQN YSKVLAEVNT SWPVKMATNA VLCCPPIALR NLIIITWEII LRGQPSCTKA YKKETNETKE TNCTDERITW VSRPDQNSDL QIRTVAITHD GYYRCIMVTP DGNFHRGYHL QVLVTPEVTL FQNRNRTAVC KAVAGKPAAH ISWIPEGDCA TKQEYWSNGT VTVKSTCHWE VHNVSTVTCH VSHLTGNKSL YIELLPVPGA KKSAKLYIPY IILTIIILTI VGFIWLLKVN GCRKYKLNKT ESTPVVEEDE MQPYASYTEK NNPLYDTTNK VKASEALQSE VDTDLHTL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards