Ribonuclease 8 (RNASE8)
Homo sapiens — UniProt Q8TDE3
Data last refreshed: (UniProt release unknown)
Key facts
Ribonuclease 8 (RNASE8) is a protein from Homo sapiens identified by UniProt accession Q8TDE3, 154 residues long. MolForge cross-references it against 0 known binders and 4 disease associations.
- UniProt accession: Q8TDE3; gene symbol RNASE8.
- Organism: Homo sapiens.
- Length: 154 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, lung adenocarcinoma and endometrial cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ribonuclease 8 |
|---|---|
| UniProt accession | Q8TDE3 |
| Gene | RNASE8 |
| Organism | Homo sapiens |
| Length | 154 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (4)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.29
- lung adenocarcinoma · score 0.18
- endometrial cancer · score 0.15
- breast adenocarcinoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TDE3-F1 | alphafold | PREDICTED | 90.39 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TDE3.
Amino-acid sequence (154 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RNASE8?
The strongest Open Targets associations for RNASE8 are neurodegenerative disease, lung adenocarcinoma, endometrial cancer and breast adenocarcinoma.
How long is the RNASE8 protein?
The Homo sapiens RNASE8 protein (UniProt Q8TDE3) is 154 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TDE3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TDE3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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