Helicase POLQ-like (HELQ)
Homo sapiens — UniProt Q8TDG4
Data last refreshed: (UniProt release unknown)
Key facts
Helicase POLQ-like (HELQ) is a protein from Homo sapiens identified by UniProt accession Q8TDG4, 1101 residues long. MolForge cross-references it against 0 known binders and 117 disease associations.
- UniProt accession: Q8TDG4; gene symbol HELQ.
- Organism: Homo sapiens.
- Length: 1101 amino acids.
- Top disease associations (Open Targets): age at menopause, reticulocyte count and menopause.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Helicase POLQ-like |
|---|---|
| UniProt accession | Q8TDG4 |
| Gene | HELQ |
| Organism | Homo sapiens |
| Length | 1101 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (117)
Diseases linked to this target (Open Targets).
- age at menopause · score 0.36
- reticulocyte count · score 0.24
- menopause · score 0.15
- breast carcinoma · score 0.12
- upper aerodigestive tract neoplasm · score 0.10
- Hereditary breast and ovarian cancer syndrome · score 0.08
- neoplasm · score 0.07
- primary ovarian insufficiency · score 0.07
- 46,XY complete gonadal dysgenesis · score 0.07
- attenuated familial adenomatous polyposis · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TDG4-F1 | alphafold | PREDICTED | 73.90 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TDG4.
Amino-acid sequence (1101 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HELQ?
The strongest Open Targets associations for HELQ are age at menopause, reticulocyte count, menopause, breast carcinoma and upper aerodigestive tract neoplasm.
How long is the HELQ protein?
The Homo sapiens HELQ protein (UniProt Q8TDG4) is 1101 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TDG4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TDG4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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