Biogenesis of lysosome-related organelles complex 1 subunit 5 (BLOC1S5)
Homo sapiens — UniProt Q8TDH9
Data last refreshed: (UniProt release unknown)
Key facts
Biogenesis of lysosome-related organelles complex 1 subunit 5 (BLOC1S5) is a protein from Homo sapiens identified by UniProt accession Q8TDH9, 187 residues long. MolForge cross-references it against 0 known binders and 129 disease associations.
- UniProt accession: Q8TDH9; gene symbol BLOC1S5.
- Organism: Homo sapiens.
- Length: 187 amino acids.
- Top disease associations (Open Targets): Hermansky-Pudlak syndrome 11, Hermansky-Pudlak syndrome and multiple sclerosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Biogenesis of lysosome-related organelles complex 1 subunit 5 |
|---|---|
| UniProt accession | Q8TDH9 |
| Gene | BLOC1S5 |
| Organism | Homo sapiens |
| Length | 187 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (129)
Diseases linked to this target (Open Targets).
- Hermansky-Pudlak syndrome 11 · score 0.62
- Hermansky-Pudlak syndrome · score 0.46
- multiple sclerosis · score 0.45
- neurodegenerative disease · score 0.45
- Alzheimer disease · score 0.45
- Parkinson disease · score 0.45
- lysosomal storage disease · score 0.45
- Hermansky-Pudlak syndrome type 7 · score 0.37
- mean corpuscular hemoglobin concentration · score 0.24
- mean corpuscular volume · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TDH9-F1 | alphafold | PREDICTED | 86.25 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TDH9.
Amino-acid sequence (187 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BLOC1S5?
The strongest Open Targets associations for BLOC1S5 are Hermansky-Pudlak syndrome 11, Hermansky-Pudlak syndrome, multiple sclerosis, neurodegenerative disease and Alzheimer disease.
How long is the BLOC1S5 protein?
The Homo sapiens BLOC1S5 protein (UniProt Q8TDH9) is 187 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TDH9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TDH9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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