Voltage-gated potassium channel regulatory subunit KCNG4 (KCNG4)
Homo sapiens — UniProt Q8TDN1
Data last refreshed: (UniProt release unknown)
Key facts
Voltage-gated potassium channel regulatory subunit KCNG4 (KCNG4) is a protein from Homo sapiens identified by UniProt accession Q8TDN1, 519 residues long. MolForge cross-references it against 0 known binders and 154 disease associations.
- UniProt accession: Q8TDN1; gene symbol KCNG4.
- Organism: Homo sapiens.
- Length: 519 amino acids.
- Top disease associations (Open Targets): multiple sclerosis, Myasthenia gravis and Muscle weakness.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Voltage-gated potassium channel regulatory subunit KCNG4 |
|---|---|
| UniProt accession | Q8TDN1 |
| Gene | KCNG4 |
| Organism | Homo sapiens |
| Length | 519 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (154)
Diseases linked to this target (Open Targets).
- multiple sclerosis · score 0.59
- Myasthenia gravis · score 0.57
- Muscle weakness · score 0.46
- small cell carcinoma · score 0.46
- secondary progressive multiple sclerosis · score 0.43
- anterior ischemic optic neuropathy · score 0.37
- primary progressive multiple sclerosis · score 0.37
- transverse myelitis · score 0.37
- atrial flutter · score 0.35
- atrial fibrillation · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TDN1-F1 | alphafold | PREDICTED | 77.88 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TDN1.
Amino-acid sequence (519 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KCNG4?
The strongest Open Targets associations for KCNG4 are multiple sclerosis, Myasthenia gravis, Muscle weakness, small cell carcinoma and secondary progressive multiple sclerosis.
How long is the KCNG4 protein?
The Homo sapiens KCNG4 protein (UniProt Q8TDN1) is 519 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TDN1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TDN1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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