CDK5 and ABL1 enzyme substrate 1 (CABLES1)
Homo sapiens — UniProt Q8TDN4
Data last refreshed: (UniProt release unknown)
Key facts
CDK5 and ABL1 enzyme substrate 1 (CABLES1) is a protein from Homo sapiens identified by UniProt accession Q8TDN4, 633 residues long. MolForge cross-references it against 0 known binders and 171 disease associations.
- UniProt accession: Q8TDN4; gene symbol CABLES1.
- Organism: Homo sapiens.
- Length: 633 amino acids.
- Top disease associations (Open Targets): BMI-adjusted waist circumference, body height and platelet count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | CDK5 and ABL1 enzyme substrate 1 |
|---|---|
| UniProt accession | Q8TDN4 |
| Gene | CABLES1 |
| Organism | Homo sapiens |
| Length | 633 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (171)
Diseases linked to this target (Open Targets).
- BMI-adjusted waist circumference · score 0.53
- body height · score 0.53
- platelet count · score 0.52
- BMI-adjusted waist-hip ratio · score 0.51
- mean platelet volume · score 0.49
- lean body mass · score 0.49
- physical activity measurement · score 0.49
- smoking behavior · score 0.49
- monocyte count · score 0.48
- leukocyte count · score 0.47
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TDN4-F1 | alphafold | PREDICTED | 55.90 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TDN4.
Amino-acid sequence (633 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CABLES1?
The strongest Open Targets associations for CABLES1 are BMI-adjusted waist circumference, body height, platelet count, BMI-adjusted waist-hip ratio and mean platelet volume.
How long is the CABLES1 protein?
The Homo sapiens CABLES1 protein (UniProt Q8TDN4) is 633 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TDN4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TDN4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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