Ribosome biogenesis protein BRX1 homolog (BRIX1)
Homo sapiens — UniProt Q8TDN6
Data last refreshed: (UniProt release unknown)
Key facts
Ribosome biogenesis protein BRX1 homolog (BRIX1) is a protein from Homo sapiens identified by UniProt accession Q8TDN6, 353 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.
- UniProt accession: Q8TDN6; gene symbol BRIX1.
- Organism: Homo sapiens.
- Length: 353 amino acids.
- Top disease associations (Open Targets): urinary bladder carcinoma, neoplasm and linear and whorled nevoid hypermelanosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ribosome biogenesis protein BRX1 homolog |
|---|---|
| UniProt accession | Q8TDN6 |
| Gene | BRIX1 |
| Organism | Homo sapiens |
| Length | 353 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (19)
Diseases linked to this target (Open Targets).
- urinary bladder carcinoma · score 0.05
- neoplasm · score 0.05
- linear and whorled nevoid hypermelanosis · score 0.05
- chronic myeloproliferative disorder · score 0.05
- eosinophil peroxidase deficiency · score 0.04
- neutropenia, severe congenital, 1, autosomal dominant · score 0.04
- ichthyosis prematurity syndrome · score 0.04
- chronic myelogenous leukemia · score 0.03
- acute myelomonocytic leukemia · score 0.03
- hemoglobin measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TDN6-F1 | alphafold | PREDICTED | 81.28 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TDN6.
Amino-acid sequence (353 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BRIX1?
The strongest Open Targets associations for BRIX1 are urinary bladder carcinoma, neoplasm, linear and whorled nevoid hypermelanosis, chronic myeloproliferative disorder and eosinophil peroxidase deficiency.
How long is the BRIX1 protein?
The Homo sapiens BRIX1 protein (UniProt Q8TDN6) is 353 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TDN6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TDN6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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