Alkaline ceramidase 1 (ACER1)
Homo sapiens — UniProt Q8TDN7
Data last refreshed: (UniProt release unknown)
Key facts
Alkaline ceramidase 1 (ACER1) is a protein from Homo sapiens identified by UniProt accession Q8TDN7, 264 residues long. MolForge cross-references it against 0 known binders and 87 disease associations.
- UniProt accession: Q8TDN7; gene symbol ACER1.
- Organism: Homo sapiens.
- Length: 264 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, hypotrichosis simplex and age-related macular degeneration.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Alkaline ceramidase 1 |
|---|---|
| UniProt accession | Q8TDN7 |
| Gene | ACER1 |
| Organism | Homo sapiens |
| Length | 264 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (87)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.40
- hypotrichosis simplex · score 0.07
- age-related macular degeneration · score 0.07
- X-linked retinal dysplasia · score 0.06
- Familial exudative vitreoretinopathy · score 0.06
- Alopecia-intellectual disability syndrome · score 0.06
- retinitis pigmentosa · score 0.06
- severe early-childhood-onset retinal dystrophy · score 0.05
- Hypotrichosis with juvenile macular degeneration · score 0.05
- congenital hypotrichosis with juvenile macular dystrophy · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TDN7-F1 | alphafold | PREDICTED | 93.33 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TDN7.
Amino-acid sequence (264 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ACER1?
The strongest Open Targets associations for ACER1 are neurodegenerative disease, hypotrichosis simplex, age-related macular degeneration, X-linked retinal dysplasia and Familial exudative vitreoretinopathy.
How long is the ACER1 protein?
The Homo sapiens ACER1 protein (UniProt Q8TDN7) is 264 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TDN7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TDN7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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