Glucosamine-6-phosphate deaminase 2 (GNPDA2)
Homo sapiens — UniProt Q8TDQ7
Data last refreshed: (UniProt release unknown)
Key facts
Glucosamine-6-phosphate deaminase 2 (GNPDA2) is a protein from Homo sapiens identified by UniProt accession Q8TDQ7, 276 residues long. MolForge cross-references it against 0 known binders and 86 disease associations.
- UniProt accession: Q8TDQ7; gene symbol GNPDA2.
- Organism: Homo sapiens.
- Length: 276 amino acids.
- Top disease associations (Open Targets): West syndrome, mathematical ability and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Glucosamine-6-phosphate deaminase 2 |
|---|---|
| UniProt accession | Q8TDQ7 |
| Gene | GNPDA2 |
| Organism | Homo sapiens |
| Length | 276 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (86)
Diseases linked to this target (Open Targets).
- West syndrome · score 0.43
- mathematical ability · score 0.29
- neurodegenerative disease · score 0.22
- body height · score 0.22
- C-reactive protein measurement · score 0.18
- IGF-1 measurement · score 0.18
- appendicular lean mass · score 0.18
- body mass index · score 0.17
- Abnormality of refraction · score 0.15
- self reported educational attainment · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TDQ7-F1 | alphafold | PREDICTED | 97.40 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TDQ7.
Amino-acid sequence (276 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GNPDA2?
The strongest Open Targets associations for GNPDA2 are West syndrome, mathematical ability, neurodegenerative disease, body height and C-reactive protein measurement.
How long is the GNPDA2 protein?
The Homo sapiens GNPDA2 protein (UniProt Q8TDQ7) is 276 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TDQ7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TDQ7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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