Relaxin-3 receptor 2 (RXFP4)
Homo sapiens — UniProt Q8TDU9
Data last refreshed: (UniProt release unknown)
Key facts
Relaxin-3 receptor 2 (RXFP4) is a protein from Homo sapiens identified by UniProt accession Q8TDU9, 374 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.
- UniProt accession: Q8TDU9; gene symbol RXFP4.
- Organism: Homo sapiens.
- Length: 374 amino acids.
- Top disease associations (Open Targets): glioblastoma multiforme, ovarian cancer and cutaneous melanoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Relaxin-3 receptor 2 |
|---|---|
| UniProt accession | Q8TDU9 |
| Gene | RXFP4 |
| Organism | Homo sapiens |
| Length | 374 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (58)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.26
- ovarian cancer · score 0.25
- cutaneous melanoma · score 0.18
- lung adenocarcinoma · score 0.18
- breast adenocarcinoma · score 0.17
- squamous cell lung carcinoma · score 0.12
- gastric adenocarcinoma · score 0.12
- MODY · score 0.04
- congenital amegakaryocytic thrombocytopenia 1 · score 0.04
- nephrotic syndrome · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TDU9-F1 | alphafold | PREDICTED | 81.27 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TDU9.
Amino-acid sequence (374 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RXFP4?
The strongest Open Targets associations for RXFP4 are glioblastoma multiforme, ovarian cancer, cutaneous melanoma, lung adenocarcinoma and breast adenocarcinoma.
How long is the RXFP4 protein?
The Homo sapiens RXFP4 protein (UniProt Q8TDU9) is 374 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TDU9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TDU9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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