Glucose-dependent insulinotropic receptor (GPR119)
Homo sapiens — UniProt Q8TDV5
Data last refreshed: (UniProt release unknown)
Key facts
Glucose-dependent insulinotropic receptor (GPR119) is a protein from Homo sapiens identified by UniProt accession Q8TDV5, 335 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.
- UniProt accession: Q8TDV5; gene symbol GPR119.
- Organism: Homo sapiens.
- Length: 335 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, endometrial cancer and prostate adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Glucose-dependent insulinotropic receptor |
|---|---|
| UniProt accession | Q8TDV5 |
| Gene | GPR119 |
| Organism | Homo sapiens |
| Length | 335 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (52)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.30
- endometrial cancer · score 0.25
- prostate adenocarcinoma · score 0.12
- type 2 diabetes mellitus · score 0.10
- Disorder of lipid metabolism · score 0.08
- diabetes mellitus · score 0.08
- type 1 diabetes mellitus · score 0.07
- cancer · score 0.05
- hyperinsulinism due to INSR deficiency · score 0.05
- hypoinsulinemic hypoglycemia and body hemihypertrophy · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TDV5-F1 | alphafold | PREDICTED | 86.74 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TDV5.
Amino-acid sequence (335 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GPR119?
The strongest Open Targets associations for GPR119 are neurodegenerative disease, endometrial cancer, prostate adenocarcinoma, type 2 diabetes mellitus and Disorder of lipid metabolism.
How long is the GPR119 protein?
The Homo sapiens GPR119 protein (UniProt Q8TDV5) is 335 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TDV5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TDV5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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