Volume-regulated anion channel subunit LRRC8C (LRRC8C)
Homo sapiens — UniProt Q8TDW0
Data last refreshed: (UniProt release unknown)
Key facts
Volume-regulated anion channel subunit LRRC8C (LRRC8C) is a protein from Homo sapiens identified by UniProt accession Q8TDW0, 803 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.
- UniProt accession: Q8TDW0; gene symbol LRRC8C.
- Organism: Homo sapiens.
- Length: 803 amino acids.
- Target class: Ion channel.
- Top disease associations (Open Targets): body height, mean platelet volume and heel bone mineral density.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Volume-regulated anion channel subunit LRRC8C |
|---|---|
| UniProt accession | Q8TDW0 |
| Gene | LRRC8C |
| Organism | Homo sapiens |
| Length | 803 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Ion channel (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (29)
Diseases linked to this target (Open Targets).
- body height · score 0.39
- mean platelet volume · score 0.34
- heel bone mineral density · score 0.34
- lymphocyte count · score 0.30
- systolic blood pressure · score 0.27
- mathematical ability · score 0.27
- diastolic blood pressure · score 0.27
- platelet crit · score 0.26
- monocyte count · score 0.10
- protein measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TDW0-F1 | alphafold | PREDICTED | 83.41 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TDW0.
Amino-acid sequence (803 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LRRC8C?
The strongest Open Targets associations for LRRC8C are body height, mean platelet volume, heel bone mineral density, lymphocyte count and systolic blood pressure.
How long is the LRRC8C protein?
The Homo sapiens LRRC8C protein (UniProt Q8TDW0) is 803 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TDW0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TDW0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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